Health First Indiana is an initiative created by Senate Enrolled Act 4, legislation passed by the 2023 Indiana General Assembly that will transform Indiana’s public health infrastructure. The legislation provides funding so local health departments (LHDs) can determine the health needs of their community and implement evidence-based programs focused on prevention. Health First Indiana establishes a public health infrastructure through a state and local partnership where services are delivered at the county level. Counties decide whether to opt-in to the new funding to provide and/or expand upon the core public health services, including trauma and injury prevention, chronic disease prevention, maternal and child health, and more.